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Mitochondria were maloriented in two patients and degeneration of membranous organelles was seen in three cases

In refractory MG treated with anti BCMA CAR T (NCT04561557), B cells returned to baseline around 18 months, with ~80% of reconstituted cells immature and a nave repertoire, suggesting long term humoral suppression and relapse prevention (65)

Notably, an increasing number of studies of carcinogenic risk factors suggested that disruptions in circadian rhythms play a more central role in tumor progression