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Metabolic studies showed that AOD9604-treated animals had increased lipolytic rates measured in isolated adipocytes, elevated circulating free fatty acid levels, and enhanced fatty acid oxidation rates

Following its phosphorylation in vivo, Fingolimod is a potent agonist of sphingosine 1-phosphate receptors, however the non-phosphorylated pro-drug also exhibits non-selective inhibition of ceramide synthases as an off-target effect 29,30