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In line with this, NAD + augmentation, via supplementation with nicotinamide riboside, reduced senescence and improved mitochondrial metabolic profiles in mesenchymal stem cells with WRN knockout ( WRN / ) and in primary fibroblasts derived from WS patients compared to controls

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Biodistribution of intratracheal, intranasal, and intravenous injections of human mesenchymal stromal cell-derived extracellular vesicles in a mouse model for drug delivery studies