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65,72,79,81,82 Given that viscosity scales exponentially with protein concentration, if the efficacious dose can be maintained through lowering the DP concentration, viscosity mitigation through formulation composition changes may not be necessary

Second, research in animal models suggests that semaglutide activates GLP-1 receptors in the central nervous system, particularly in the brainstem area postrema and nucleus tractus solitarius, which are regions responsible for controlling nausea and vomiting responses

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