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Surgeons rarely operate before 1415 years old, and only when growth plates are nearly closed, hormone labs are normal, and the enlargement has persisted for at least 12 months

In our previous studies with both bulk (Gill et al, 2014) and scRNA-seq (Yuan et al, 2018), we observed that the mesenchymal phenotype was strongly associated with recurrent tumors and that the principal remaining glioma cell type with neural lineage resemblance was astrocyte-like