mrp1 glutathione sirt1 deficiency promotes age-related heart failure through enhancing ferroptosis via GATA4-HADHA-GPX4 axis Molecular Medicine Reports

Metal binding peptides can be prepared by standard solid-phase peptide synthesis (SPPS) protocols, and optionally incorporate synthetic or non-naturally occurring amino acids and peptide backbone modifications

Because conventional bisulfite sequencing cannot distinguish between DNA methylation and hydroxymethylation, Massart et al

The PI3K/AKT axis drives fibrotic responses via AKT/mTOR and PAK2/c-Abl signaling [43, 44], while the MEK/ERK pathway contributes to pulmonary fibrosis, particularly under Bmi-1 deficiency [45]

376 Arimoclomol, a co-inducer of HSP27 and HSP70, has demonstrated efficacy in ALS and HD models by reducing protein aggregation and improving neuronal survival