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Conversely, PHGDH knockdown or inhibition of its enzymatic activity leads to ROS accumulation and induces oxidative stress-mediated death in HCC cells ( 3.3 Shaping the immunosuppressive tumor microenvironment Metabolic reprogramming represents one of the core hallmarks of malignant tumors

17 Early findings support that restoring Glutathione balance may improve cognitive performance and reduce oxidative stress in the aging brain, thanks to its powerful antioxidant properties, though findings remain preliminary

It has been reported that L-carnitine as a supplement can be useful in the treatment of hypertension (37), diabetes mellitus (6, 7), NAFLD (34), heart failure (38), coronary artery disease (39), liver cirrhosis (40), muscle injury (41), dyslipidemia (42), migraine (43), Alzheimer's disease (44), and other chronic diseases

Moreover, the increase in reactive oxygen species (ROS) and reactive nitrogen species (RNS) in endothelial cells due to systemic inflammation might alter claudins and occludins, which are critical structural components of the BBB