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Diabetes 49 , 12191223 (2000)

Among these factors, c-Myc exhibited the most significant differential expression, and subsequent experimental validation further confirmed that c-Myc was markedly downregulated under Gln deprivation (Fig

In various tumor types, p53 mutations not only result in the loss of its tumor suppressor function but may also confer new oncogenic functions to the mutated p53, a phenomenon termed gain-of-function (GOF) ( The p53 protein plays a crucial role in cell cycle regulation and apoptosis