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Description

Sex steroids further enhance the function of the GH-IGF-axis, most likely by attenuating pituitary and hypothalamic sensitivity to IGF-I negative feedback (78)

The standard titration schedule of 4 weeks per dose level is a minimum, not a mandate

Risks and Considerations: Some patients may experience a temporary increase in pain or swelling following the injection

this results in reduced transcription of mitochondrial ribosomal proteins and mitochondrial transcription factors, and subsequently halting protein translation 101,102