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Cidofovir (CDV) is used against cytomegalovirus and adenovirus infections but has limited clinical utility because of its poor bioavailability and high occurrence of acute nephrotoxicity

The development of potent anticancer drugs often occurs through natural compounds, structural alterations of existing natural compounds, or the production of entirely novel molecules

15 : 351369 Kamata H, Honda S, Maeda S, Chang L, Hirata H and Karin M (2005) Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases

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