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Domej, W., Oettl, K., & Renner, W

The brain requires a very large amount of energy for its function, and these defects suggest that the aging brain is starved of energy, which could result in cognition decline. GlyNAC supplementation in old mice corrected brain glutathione deficiency, improved brain glucose transporters, reversed mitochondrial dysfunction and improved cognition

Subjects that qualified for the study then underwent an initial FDG PET scan along with qualitative evaluation of their symptoms using the 36-Item Short Form Survey, the Mental Health Inventory from the Medical Outcomes Study Survey, and the Perceived Deficits Questionnaire ( NAC Intervention Subjects were randomized using a permuted block method (1:1 ratio using sealed envelopes with the allocation) to either receive intravenous/oral NAC or were placed in the waitlist control condition

patients who have had inhalation treatments of acetylcysteine without incident may still react to subsequent inhalation with increased airways obstruction