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As a major cell type in kidney, proximal tubular cell produce ATP via fatty acid -oxidation (FAO) in mitochondria ( via controlling the transcription and translation of FAO-related enzymes (Xu et al., 2022), which could further trigger the impairment of mitochondrial structure and function ( 3 Natural products for regulating mitochondrial function 3.1 Enhancing mitochondrial biogenesis and energetics It is widely found that impaired mitochondrial biogenesis and energetics contribute to the pathogenesis of kidney diseases (Weinberg, 2011

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Diabetic glomerulosclerosis is a defining feature of diabetic nephropathy

Splice isoform analysis of GATM Isoform-specific GATM gene expression data were generated by reanalysis of RNAseq fastq files using the hg38 build through Astrocyte 2.2.0 to derive relative expression of transcript variants