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Simultaneously, glutathione-S-transferase (GST) activity decreases by 72%, reducing the cellular capacity to clear toxic metabolites ( 3.3 Oxidative stress and mitochondrial dysfunction EED-induced oxidative stress represents a central mechanism underlying reproductive toxicity, with mitochondrial dysfunction serving as both cause and consequence of excessive reactive oxygen species production

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This has nothing to do with b12 status and everything to do with excessive caloric deficit and insufficient protein intake relative to the rate of weight change

Remember, B12 injections do not cause weight loss