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doi: 10.1021/acschemneuro.2c00819 191

The result is amplified growth hormone signaling in the tissues that need it most for repair

The progressive accumulation of oxidative stressinduced mtDNA damage can exceed a functional threshold, resulting in respiratory chain defects and global mitochondrial impairment

Further, they observed that under heat stress the accumulation of ROS reduced significantly by the exogenous application of BiP5 and HSP-7017 proteins