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Those with active malignancy, certain pituitary issues, or poorly controlled diabetes may not be appropriate and require careful medical evaluation first

Moreover, chronic or prolonged supplementation with ALA after the cessation of stress stimuli may not provide additional metabolic or anti-oxidative benefits, and in some cases, may partially associated with histopathological changes in liver or induce pro-oxidant effects under normal physiological conditions (5052)

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It is found in the blood of most mammals and is particularly important in regulating the growth, development, and death of vascular endothelial cells, the cells that line the inside of blood vessels