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Systemic side effects may include dizziness, facial flushing, headaches, and mild nausea , particularly during the initial weeks of therapy

However, under oxidative stress, Nrf2 stimulates the expression of several redox genes, such as glutathione synthetase ( Gss ), glutathione peroxidase 4 ( Gpx4 ), glutamate-cysteine ligase catalytic subunit ( Gclc ), Slc7a11 , superoxide dismutase ( Sod ) and catalase ( Cat ) [7, 8]

Its similar to the natural redness you see when you blush, where increased blood flow leads to a temporary change in skin color