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Dependence on skeletal muscle metabolic state

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For instance, a high acetyl-CoA/CoA ratio in the mitochondrial matrix inhibits pyruvate dehydrogenase (PDH) that catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA (Pietrocola et al., 2015)

A senior UKA doctor remarked at the time: "Wonder how much other medical stuff [Salazar] may drive and not keep us informed." UK Athletics said any concerns about four-time Olympic champion Farah's medication were addressed when head of endurance Barry Fudge took over in July 2011 as liaison between the Oregon Project and UKA