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3 The role of ferroptosis in female reproductive disorders 3.1 The impact of ferroptosis on the process of follicular development ROS and antioxidants in the ovaries play critical regulatory roles during oocyte maturation, fertilization, and embryonic development and implantation (98)

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In vitro evidence has shown that high-glucose-induced calcium (Ca 2+ ) secretion leads to fragmented mitochondria, resulting in increased ROS production and ERK 1/2 activation (Yu et al., 2011)

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