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Remarkably, Erastin highly increased OCR in LDHB KD (siLDHB + Erastin) but not in control A549 cells (siNT + Erastin) ( Figure 4d, Supplementary Figure 8c ), suggesting that cancer cells subjected to combined inhibition of LDHB and SLC7A11 undergo a high level of OXPHOS

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First, routine screening for vitamin B12 deficiency should be incorporated into primary care for high-risk populations such as older adults, women of reproductive age, vegetarians, and patients with diabetes or chronic use of metformin or proton pump inhibitors