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Heme produces signaling molecules, such as CO, biliverdin (BV), BR and Fe 2+ , through the catalysis of HO-1

The GSH binding motif of GPx1 is comprised of four arginine (Arg or R) and one lysine (Lys or K) residues surrounding the Sec of catalytic tetrad [8, 17, 18]

Its core action involves downregulating pro-inflammatory cytokines (TNF-, IL-6, IL-1) via inhibition of NF-B, MAPK, and TLR signaling

Furthermore, induction of HO-1 in SLE confers an anti-inflammatory phenotype to monocytes and DCs, while myeloid cells in these patients show downregulated HO-1 levels, suggesting that its deregulation is involved in disease progression (90)