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While modulation of the GSH-antioxidant system has provided promising preclinical results, some of these compounds demonstrate unacceptable toxicity profiles (eg, buthionine sulfoximine)

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Pan, J., et al.,26S proteasome activity is down-regulated in lung cancer stem-like cells propagated in vitro

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In the Unani medical system, it is employed as a diuretic (542)

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mTOR regulates phagosome and entotic vacuole fission

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