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Common causes of iron deficiency include: If untreated, iron deficiency can progress to iron-deficiency anemia, leading to severe fatigue, pale skin, and increased heart rate

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IRES: As used herein, the term internal ribosome entry site or IRES refers to an RNA sequence or structural element ranging in size form 10 nucleotides to 1,000 nucleotides or more which is capable of initiating translation of a polypeptide in the absence of a normal RNA cap structure