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Furthermore, studies suggest that these alkaloids may also directly induce programmed cell death in neurons and glial cells via activation of the PPAR/NF-B/caspase-3-dependent apoptotic pathway, offering a novel explanation for their potential long-term or subacute neurotoxic effects [42]

2021 ESC Guidelines on cardiovascular disease prevention in clinical practice: Developed by the Task Force for cardiovascular disease prevention in clinical practice with representatives of the European Society of Cardiology and 12 medical societies With the special contribution of the European Association of Preventive Cardiology (EAPC) (vol 42, pg 3227, 2021)