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J Biol Chem 285 : 2855328564

The two therapies fall short in precisely targeting tumor areas, leading to risks of incomplete cancer cell removal and posttreatment recurrence

From what has been mentioned so far, it is very likely that the carcinogenic effect of IDH1 R132 and IDH172 is mediated through the elevated cellular (D)-2HG levels originating from cytoplasm by IDH1 R132 or from mitochondria by IDH2 R172 (where it exits the mitochondria and enters the cytoplasm)

"Pilot Study of the Effect of Methyl B12 Treatment on Behavioral and Biomarker Measures in Children with Autism." The Journal of Alternative and Complementary Medicine 16.5 (2010): 555-60