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This strategy is more relevant for enhancing treatment with DNA-damaging chemotherapeutics than with targeted therapeutics, as the chemotherapeutic treatments generally lead to SASP-induction 47

For genotoxic and carcinogenic compounds or compounds for which data presents high uncertainty on their effects and no intake can be defined as safe, the Margin of Exposure (MoE) approach is used, as suggested by EFSA (Barlow et al

This promises to reveal the conditions under which plasticity in the visual pathway can be maintained or even induced: this would open up the possibility whereby modulation of "molecular switches" with specific drugs could allow or facilitate the regeneration of damaged pathways

These findings could mark a major advancement in the treatment of CHB, offering patients a more effective strategy to manage the disease