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The primary peritoneal macrophages from the Gstp / mice showed a higher HMGB1 release level than that from wild type C57BL/6 mice (Figure 2A)

Epstein Shochet G, Brook E, Bardenstein-Wald B, Shitrit D

Similarly, in a STZ-induced diabetic hypertension rat model, ALT-711 combined with nifedipine produced superior outcomes compared to monotherapy by further lowering SBP and DBP, enhancing vasodilatory mediators (prostacyclin, NO), and reducing prepro-endothelin-1 expression [163]