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GHK Basic Studies on Insulin-Related Genes and Cellular Longevity Research indicates that GHK may modulate insulin and insulin-like gene expression, possibly impacting cellular lifespan

The pathogenesis of sarcopenia is complex and multifaceted: the chronic catabolic condition, increased energy expenditure, reduced appetite, side effects of multiple therapies, alterations in circulating levels of hormones, low protein synthesis, and the presence of ascites or portosystemic shunts are all factors contributing to muscle atrophy in cirrhotic patients [23]

10.1038/s41392-021-00762-6 32 LivakK

Cell Commun Signal 22:7 McElwee MK, Song MO, Freedman JH (2009) Copper activation of NF-kappaB signaling in HepG2 cells