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The JAK/STAT signaling pathway, as the main target for inhibiting the action of a variety of cytokines (221), is involved in the signal transduction of many key cytokines for the pathogenesis of RA and has been considered as a potential target for the treatment of RA (222)

However, as the MVD progresses, the dog's ability to produce active BNP declines, lessening its ability to counter the effects of RAAS activation

122) A similar terpolymerization was performed using three kinds of monomers, -pentadecalactone, diethyl succinate, and 1,4-butanediol, by CALB catalyst desirably at 95 C via a two-stage vacuum technique

Bibcode:1980PNAS...77.5754S