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The graphical LASSO model with EBICglasso reduced the probability of false connections

361 NAD + also regulates oxidative stress in cellular senescence by regulating sirtuins and PARPs

In the HD model, reduced expression and deacetylase activity of SIRT3, which in turn prevents the deacetylation of LKB1 and SOD2, leading to a decrease in the level of NAD + , defects in mitochondrial biogenesis and accumulation of ROS