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However, given the overlap inflammatory effects between plasma and all tissues in previous and our work, we suspected that the circulationderived proteome masked organspecific effects

56 In clinical studies, purple grape juice lowered platelet reactivity in healthy subjects

Thus, by lacking SIRT1 activity, ageing results in a scenario where AMPK is activated due to energy-scarce conditions, but this results in mitotic arrest through phosphorylation of p53 and increasing p16 expression (Wiley et al, 2016)