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Excessive hair loss or thinning hair may indicate an underlying issue or disrupted hair growth cycle

Indeed, proteasome-dependent proteolysis of carbonylated proteins that were extensively present in late log phase epimastigote cultures was suggested to signal metacyclogenesis (Cardoso et al., Nucleotides Synthesis and DNA Replication Cellular DNA synthesis and proliferation, as well as DNA repair mechanisms depend on the production of a balanced supply of deoxyribonucleotides (dNTPs)