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(2000), Horm Res 53(Suppl 3), PubMed 10971106 Statistics from preclinical literature AOD-9604 = modified fragment of hGH 177191 + N-terminal Tyr (sequence Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe), molecular weight 1815.1 Da Developed at Metabolic Pharmaceuticals (Australia) based on the work of professor Frank Ng (Monash University) in the 1990s Standard experimental dose in obesity clinical trials: 1 mg/day subcutaneously (Phase 2b, Heffernan et al.) Mechanism: stimulation of 3-adrenergic receptors in adipose tissue, increased lipolysis and fatty acid oxidation without activation of the hGH receptor (no IGF-1 increase) Phase 2b clinical trial (2007, 300 patients): weight reduction ~2.8 kg vs placebo over 12 weeks FDA status: NDI rejection (2014) as a dietary supplement

This allows for more gradual dose adjustments to minimize side effects and optimize weight loss outcomes

Who Should Consider MOTS-C

When billing CPT code 96372, ensure the following are included in the medical record: Name and dosage of the drug administered Route of administration (subcutaneous or intramuscular) Site of injection Time and date of service Reason for the injection (diagnosis or medical necessity) Signature and credentials of the administering provider Accurate and complete documentation supports the claim, validates medical necessity, and helps protect against audits and reimbursement issues