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The pathway for the initial glycan processing and synthesis of core N -glycans in the endoplasmic reticulum (ER) is evolutionally conserved in all eukaryotes and is essential for cell viability as part of the protein folding machinery (Nagashima et al., 2018)

The HECT domain of full-length Nedd4-2 displays a typical bi-lobal architecture and adopts a T-shaped conformation (Supplementary Fig

also reported that the inhibition of GPX4 impaired the OT-1 T cells antigen-specific killing of cancer cells, and this effect was rescued by ferroptosis inhibitors, vitamin E and Fer-1.[46] Moreover, GPX4 has already been shown to control lipid oxidation and to support physiological T cell responses [47]

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