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Surgery 100:815821 Holeek M (2020) Why are branched-chain amino acids increased in starvation and diabetes

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After activation, the Wnt/-catenin pathway causes -catenin to become stable and move to the nucleus, where it uses T-cell factor/lymphoid enhancer-binding factor (TCF/LEF) transcription factors to activate and control downstream target genes, ultimately increasing the expression of genes related to cell migration, differentiation, proliferation, and survival (198, 199)

Some drugs, such as doxorubicin, activate the NF-B pathway, leading to the transcription of pro-inflammatory cytokines and survival genes