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85, 913 (2013), Application(s): Autophagy detection by flow cytometry in breast cancer cells, Abstract Arenobufagin, a natural bufadienolide from toad vonem, induces apoptosis and autophagy in human hepatocellular carcinoma cells through inhibition of PI3K/Akt/mTOR pathway: D.M

Briefly, both enzymatic and non-enzymatic crosslinks affect the collagen structure, altering both tissue biomechanics ( e.g ., altered tissue elastic modulus, ultimate tensile strength, stress relaxation, etc .) and failure mechanisms ( e.g ., crosslink breakage, load transfer, etc .)