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When this pathway gets overactive (which happens with age, stress, and illness), inflammation can spiral out of control

An early reduction in GH peak amplitude in preproghrelin-deficient male mice has a minor impact on linear growth

Ferroptosis inducers, such as sorafenib, inhibit the function of System Xc, leading to impaired intracellular GSH synthesis [116]

Abbreviations GPX-like: Glutathione peroxidase-like GR: Glutathione reductase GSH: Reduced form of glutathione GSSG: Oxidised form of glutathione HNO: Nitroxyl NOx: Nitric oxide derivatives ONOO : Peroxynitrite RNS: Reactive nitrogen species ROS: Reactive oxygen species References Arasimowicz-Jelonek M, Floryszak-Wieczorek J, Suarez S, Doctorovich F, Sobieszczuk-Nowicka E, Bruce King S, Milczarek G, Rbi T, Gajewska J, Jagodzik P, ywicki M (2022) Discovery of endogenous nitroxyl as a new redox player in Arabidopsis thaliana