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Description

Apoptosis regulation at the mitochondria membrane level

It exerts biological functions such as antioxidant and metabolic regulation through selenoproteins, which are key biomolecules

Mitochondrial reactive oxygen species activation of p38 mitogen-activated protein kinase is required for hypoxia signaling

We found that: (i) cell production of hydrogen peroxide and superoxide anion were non significantly altered among different experimental samples (data not shown), but, by contrast, (ii) the GSH intracellular levels were reduced by TMZ and more dramatically by QN/TMZ association