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GHK-Cu has been investigated for ECM remodelling, fibroblast and keratinocyte cellular pathway modulation, antioxidant chemistry, and gene-expression regulation, with the literature anchored by half a century of work since the original Pickart-laboratory characterisation

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This organism lives naturally on the skin, but in those with compromised skin barriers (as is common in eczema), it can overgrow and become problematic