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In some embodiments, the invention encompasses a method of providing muscular therapy by contacting a cell expressing NNMT with a NNMT inhibitor (such as a cation of Formula I or IA, or otherwise disclosed herein) and one or more chemical entities (e.g., nicotinamide riboside, nicotinamide mononucleotide) that increases intracellular NAD+ levels to provide muscular therapy

Article PubMed Google Scholar Park JH, Restrepo C, Norton R, Mandel S, Sharkey PF, Parvizi J (2013) Common peroneal nerve palsy following total knee arthroplasty: Prognostic factors and course of recovery

The Journal of neuroscience : the official journal of the Society for Neuroscience 31(14):54145425

doi: 10.1016/j.arr.2023.102035 119 WangD.PengY.XieY.ZhouB.SunX.KangR.et al