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GLP-1 receptor agonists happen to address all three of these dimensions simultaneously

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Cell 156(5):10451059 Vijay-Kumar M, Aitken JD, Carvalho FA, Cullender TC, Mwangi S, Srinivasan S et al (2010) Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5

These include a predicted Se-related transporter (YedE), a redox protein (YedF), a Se-specific transcriptional regulator (LysR_Se) likely responsible for regulating Sec-decoding gene expression, and a potential chaperone protein (DUF3343) implicated in the intracellular transport of Se or sulfur 32