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This protection is likely due to mROS-mediated activation of HIF-1, which enhances LDHA expression while suppressing PDH activity, thereby promoting lactate accumulation over mitochondrial oxidative metabolism [67]

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[1] At doses above 30 grams, transient gastrointestinal discomfort has been reported, but lower doses in the 3 to 15 gram range are well-tolerated by the vast majority of individuals