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Glutamate Immunoexcitotoxicity in PD Extensive microglial activation in and around the SNpc was first observed more than 30 years ago in autopsies of patients with PD (McGeer et al., 1988)

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RSL3 induces ferroptosis via GPX4 inhibition [139], while TfR1-mediates ferritin endocytosis promotes ferroptosis by increasing intracellular iron [137]