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Consistent with their elevated SLC7A11 expression level, IRE1-null MDA-MB-231 cells also demonstrated increased cystine uptake, which can be inhibited by IRE1 reconstitution (Supplementary Fig

Group 15) showed significant GST inhibition in all species studied

Histological evaluations demonstrated more organized muscle architecture, while functional testing showed superior recovery of muscle performance compared with untreated controls (17)