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Because biologically, females tend to have a higher percentage of body fat and a lower percentage of body water compared to men, they tend to achieve higher blood alcohol concentration when they drink the same amount of alcohol as men, even when accounting for differences in size

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Some studies indicate that the risk is also due to higher homocysteine levels[ref], while other studies show that it may be due to the methylation of certain genes.[ref] Meta-analyses showed that the MTHFR C677T variant increased the risk of migraines with aura for all population ancestry groups