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Annu Rev Plant Physiol Plant Mol Biol 51:141165 Li Y, Dhankher OP, Carreira L, Balish RS, Meagher RB (2005) Arsenic and mercury tolerance and cadmium sensitivity in Arabidopsis plants expressing bacterial -glutamylcysteine synthetase

The lack of a physiological mechanism for iron excretion adds another reason, besides its toxic propensity, to subject iron to strict regulation

for example, the GPX4 gene becomes methylated following treatment of nucleus pulposus cells by HCys, resulting in lower levels of both GPX4 mRNA and protein [79]

When OCTN2 malfunctions, it can lead to Primary Carnitine Deficiency (PCD), a condition marked by widespread carnitine depletion and serious health issues, including fertility problems