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For instance, dual pH- and redox-responsive polymeric and micellar carriers have been optimized for curcumin, exhibiting controlled degradation and sustained intracellular release in tumor microenvironments (Pillarisetti et al., 2017)

Decreased relative TEN1 gene expression to 0.77

Several development programmes for the treatment of excessive daytime sleepiness [155, 156], orthostatic hypotension [157], and cognitive impairment [158, 159] were discontinued