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Moreover, the same NO/cGMP signaling was effective in survival cell response to GSH depletion in skeletal muscle cells ( On the basis of these knowledge, it is not surprising that alterations in GSH homeostasis have been implicated in the etiology and/or progression of many human diseases ( In this review we briefly summarize the mechanisms of GSH synthesis and homeostasis, while we will focus on the strict connection between GSH levels and oxidative/nitrosative stress and on the downstream redox changes that modulate signaling pathways involved in viral infection and autophagy (ATG)

Yin X, Xu R, Song J, Ruze R, Chen Y, Wang C, et al

Figure 8 4.4 Relationship between oxidative stress and ferroptosis in AD 4.4.1 Relationship between mitochondrial oxidative stress abnormalities and ferroptosis in AD OS is a shared pathological feature of ferroptosis and AD