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Monitoring the treatment of urea cycle disorders using phenylbutyrate metabolite analyses: still many lessons to learn

Proposed mechanisms for the role of iron in neurodegeneration include increased oxidative stress, possibly due to enhanced generation of reactive oxygen species (ROS) associated with increased protein aggregation [26, 117]

These events were predominantly mild to moderate and transient, and only 5.9% of participants discontinued treatment, indicating an overall acceptable safety and tolerability profile

Using a preclinical model, the authors evidenced that chronically fentanyl-treated animals (male Brown Norway X F344 rats aged 12, 18, 24, and 30 months) lost both fat and lean mass during early and late drug administration, as well as during early withdrawal, independently from aging (Mitzelfelt et al., 2011)