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*Correspondence: Wenan Xu, [email protected]

The lactate-driven acidification directed monocyte differentiation (in the presence of GM-CSF and IL-4) toward immunosuppressive tumor-associated DCs with impaired CD8 + T cell priming capacity

Schultz et al., 2012[130]

Excess lysosomal free copper leads to their bursting, causing liver injury and excessive release of free copper in the blood, increasing the risk of hemolysis and copper flooding in other organs