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4.2.3 Dual-substrate-competitive inhibitors Dual-substrate-competitive inhibitors compete with the both substrates (SAM and NAM) for the binding sites in NNMT, thereby increasing inhibitors activity and selectivity (Gao et al., 2021)

doi: 10.1182/bloodadvances.2021005220

B12 also plays a significant role in preventing vascular and cognitive diseases through its involvement in the conversion of homocysteine to methionine and then to Sadenosylmethionine